Department of Radiology Research
Welcome to the research website of the Department of Radiology at Radboud University Nijmegen Medical Centre.
Research at the Department of Radiology has a strong focus on early detection and early treatment of common diseases. It covers fundamental research on a molecular level, development of new medical devices and software tools, and translates these results to clinical applications that can be used in daily routine. Our mission is to bridge the gap between research and practice and to help shape the future of healthcare. We use technology to make healthcare more affordable by increasing automation of diagnostic and therapeutic procedures, thus freeing manpower for those areas in patient care in which the "human touch" is most needed.
The three fundamental science groups cover ultrasound (MUSIC), biomedical MR (BioMR) and diagnostic image analysis (DIAG). Clinical research is mainly focused on prostate, breast, chest and vascular disease.
Prof. Arend Heerschap and dr. William Leenders have published a paper in Cancer Research entitled: IDH1 R132H mutation generates a distinct phospholipid metabolite profile in gliomas.
Many glioma patients harbor specific mutations in the isocitrate dehydrogenase gene IDH1, which associate with a relatively better prognosis. IDH1-mutated tumors produce the oncometabolite 2-hydroxyglutarate. Since IDH1 regulates several pathways leading to lipid synthesis, they hypothesized that IDH1 mutant tumors would display an altered phospholipid metabolite profile which would impinge on tumor pathobiology. Their results provide evidence that the IDH1-R132H mutation alters phospholipid metabolism in gliomas involving phosphoethanolamine and glycerophosphocholine. These new noninvasive biomarkers can assist in the identification of the mutation and in research toward novel treatments that target aberrant metabolism in IDH1-mutant glioma. To read the full article, please click here.
See more in the Highlight Archive.
- September 12, 2014: Symposium on diabetes: Diabetes 2014: from Evolution to Revolution?
- September 10, 2014: Yi Sun will defend his PhD thesis Magnetic resonance imaging of engineered tissues - Enhanced contrast and ultrashort echo time MRI.
- September 9, 2014: Ernst Scholten will defend his PhD thesis SubSolid Nodules in lung cancer screening.
- June 25, 2014: Thiele Kobus obtained her PhD degree for her thesis Assessment of Prostate Cancer Aggressiveness with Magnetic Resonance Spectroscopic Imaging and Diffusion-weighted Imaging.
- May 27, 2014: Guide van Schie obtained his PhD degree for his thesis Image Computing Methods for Accurate and Efficient Interpretation of Digital Breast Tomosynthesis.
- February 12, 2014: Tao Tan obtained his PhD degree for his thesis Automated 3D Breast Ultrasound Image Analysis.
- January 27, 2014: Patricia Figueiredo Nunes obtained her PhD degree for her thesis Interplay of glucose and lipid metabolism in skeletal muscle and liver assessed by multinuclear magnetic resonance spectroscopy.
- December 9, 2013: Valerio Zerbi obtained his PhD degree for his thesis Impact of nutrition on brain structure and function - A magnetic resonance imaging approach in Alzheimer mouse models.
- Wednesday November 27, 2013, Laurens Hogeweg obtained his PhD degree for his thesis Automatic detection of tuberculosis in chest radiographs at 4.30 pm in the Aula of the Radboud University.
- November 19, 2013: Denise Hermans obtained her PhD degree for her thesis entitled Infantile hemangiomas, the implications of the changing landscape of treatment after propranolol.
- October 18, 2013: Melissa Chrispijn obtained her PhD degree for her thesis Phenotype and treatment of polycystic liver disease - Where hepatology meets radiology.
- October 4, 2013: Caroline Hoeks obtained her PhD degree for her thesis Multiparametric MR imaging and MR guided biopsy: prostate cancer diagnosis and risk-stratification.
- September 26, 2013: Rik Somford obtained his PhD degree for his thesis Challenges in diagnosis, grading and staging of localized prostate cancer.
- September 9, 2013: Hetty Prinsen obtained her PhD degree for her thesis Fatigue in cancer survivors: a (neuro)physiological approach.
- May 28, 2013: Hanneke Meijer obtained her PhD degree for her thesis Magnetic resonance lymphography and lymph node irradiation in prostate cancer.
- February 1, 2013: Bram van Ginneken was awarded a VICI grant, in the NWO Vernieuwingsimpuls programme, for his proposal Lung CT Screening: More for Less.
For older news, see the News Archive.