Radboud Imaging Research
Welcome to the research website of the Department of Radiology and Nuclear Medicine at Radboud university medical center, Nijmegen.
Our research has a strong focus on early detection and early treatment of common diseases. It covers fundamental research on a molecular level, development of new medical devices and software tools, and translates these results to clinical applications that can be used in daily routine. Our mission is to bridge the gap between research and practice and to help shape the future of healthcare. We use technology to make healthcare more affordable by increasing automation of diagnostic and therapeutic procedures, thus freeing manpower for those areas in patient care in which the "human touch" is most needed.
The three fundamental science groups cover ultrasound (MUSIC), biomedical MR (BioMR), diagnostic image analysis (DIAG) and tracer research (TRACER). Clinical research is mainly focused on prostate, breast, chest and vascular disease.
Prof. Arend Heerschap and dr. William Leenders have published a paper in Cancer Research entitled: IDH1 R132H mutation generates a distinct phospholipid metabolite profile in gliomas.
Many glioma patients harbor specific mutations in the isocitrate dehydrogenase gene IDH1, which associate with a relatively better prognosis. IDH1-mutated tumors produce the oncometabolite 2-hydroxyglutarate. Since IDH1 regulates several pathways leading to lipid synthesis, they hypothesized that IDH1 mutant tumors would display an altered phospholipid metabolite profile which would impinge on tumor pathobiology. Their results provide evidence that the IDH1-R132H mutation alters phospholipid metabolism in gliomas involving phosphoethanolamine and glycerophosphocholine. These new noninvasive biomarkers can assist in the identification of the mutation and in research toward novel treatments that target aberrant metabolism in IDH1-mutant glioma. To read the full article, please click here.
See more in the Highlight Archive.
- June 23, 2015: Anton Meijer will defend his PhD thesis Clinical Application of Brain MRI - From basic to advanced imaging.
- May 27, 2015: Wietske Woliner-van der Weg will defend her PhD thesis Clinical application of quantative SPECT in patient specific dosimetry and beta cell quantification.
- May 22, 2015: Stijn Muselaers will defend his PhD thesis Targeting renal cell carcinoma with radiolabeled antibodies.
- Apr 25, 2015: Dennis Vriens has defended his PhD thesis Quantitative characterisation of solid tumours by 18F-FDG PET. What's in a number?.
- Apr 24, 2015: Albert Gubern-Mérida has defended his PhD thesis Automated Analysis of Magnetic Resonance Imaging of the Breast.
- January 23, 2015: Geert Litjens has obtained his PhD for his thesis Computerized detection of cancer in multi-parametric prostate MRI.
- December 1, 2014: Linda Heijmen obtained her PhD degree for her thesis Multimodality imaging in colorectal cancer.
- September 12, 2014: Symposium on diabetes: Diabetes 2014: from Evolution to Revolution?
For older news, see the News Archive.