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Radboud Imaging Research

Welcome to the research website of the Department of Radiology and Nuclear Medicine at Radboud university medical center, Nijmegen.

Our research has a strong focus on early detection and early treatment of common diseases. It covers fundamental research on a molecular level, development of new medical devices and software tools, and translates these results to clinical applications that can be used in daily routine. Our mission is to bridge the gap between research and practice and to help shape the future of healthcare. We use technology to make healthcare more affordable by increasing automation of diagnostic and therapeutic procedures, thus freeing manpower for those areas in patient care in which the "human touch" is most needed.

The four fundamental science groups cover ultrasound (MUSIC), biomedical MR (BioMR), diagnostic image analysis (DIAG) and tracer research (TRACER). Clinical research is mainly focused on prostate, breast, chest and vascular disease.

With the menu on the right you can learn more about our researchers, view or download publications or navigate to any of the research groups within the department.

Highlight

Highlight breukels.png
Vincent Breukels et al. have published a paper in "NMR in Biomedicine": Direct dynamic measurement of intracellular and extracellular lactate in small-volume cell suspensions with (13) C hyperpolarized NMR.

Hyperpolarized (HP) (13) C NMR allows enzymatic activity to be probed in real time in live biological systems. The use of in vitro models gives excellent control of the cellular environment, crucial in the understanding cancer metabolism. The increased conversion of pyruvate-to-lactate in cancer cells, the so-called Warburg effect, is well studied with HP (13) C NMR. Unfortunately, the equally important metabolic step of lactate transport out of the cell remains undetected, because intracellular and extracellular lactate are measured as a single resonance.

Breukels et al. present a new setup for live in vitro systems with the spectral resolution to separate the intracellular and extracellular lactate resonances. Tested with suspensions of prostate cancer carcinoma cells (PC3) in combination with HP [1-(13) C]pyruvate, they show the existence of a 3-Hz chemical shift difference between intracellular and extracellular lactate. The dynamic and simultaneous detection of both lactate pools allows lactate transport to be measured directly in addition to the pyruvate-to-lactate label conversion rate. This will help discriminating different prostate cancer types as well as increase our understanding in cancer metabolism in general.

See more in the Highlight Archive.

News

For older news, see the News Archive.