Radboud Imaging Research
Welcome to the research website of the Department of Radiology and Nuclear Medicine at Radboud university medical center, Nijmegen.
Our research has a strong focus on early detection and early treatment of common diseases. It covers fundamental research on a molecular level, development of new medical devices and software tools, and translates these results to clinical applications that can be used in daily routine. Our mission is to bridge the gap between research and practice and to help shape the future of healthcare. We use technology to make healthcare more affordable by increasing automation of diagnostic and therapeutic procedures, thus freeing manpower for those areas in patient care in which the "human touch" is most needed.
The four fundamental science groups cover ultrasound (MUSIC), biomedical MR (BioMR), diagnostic image analysis (DIAG) and tracer research (TRACER). Clinical research is mainly focused on prostate, breast, chest and vascular disease.
Hyperpolarized (HP) (13) C NMR allows enzymatic activity to be probed in real time in live biological systems. The use of in vitro models gives excellent control of the cellular environment, crucial in the understanding cancer metabolism. The increased conversion of pyruvate-to-lactate in cancer cells, the so-called Warburg effect, is well studied with HP (13) C NMR. Unfortunately, the equally important metabolic step of lactate transport out of the cell remains undetected, because intracellular and extracellular lactate are measured as a single resonance.
Breukels et al. present a new setup for live in vitro systems with the spectral resolution to separate the intracellular and extracellular lactate resonances. Tested with suspensions of prostate cancer carcinoma cells (PC3) in combination with HP [1-(13) C]pyruvate, they show the existence of a 3-Hz chemical shift difference between intracellular and extracellular lactate. The dynamic and simultaneous detection of both lactate pools allows lactate transport to be measured directly in addition to the pyruvate-to-lactate label conversion rate. This will help discriminating different prostate cancer types as well as increase our understanding in cancer metabolism in general.
See more in the Highlight Archive.
- November 25, 2015: Bianca Lassen will defend her PhD thesis at 12:30.
- November 19, 2015: Colin Jacobs will defend his PhD thesis at 14:30
- September 24, 2015: Jaime Melendez will defend his PhD thesis at 10:30.
- September 14, 2015: Barbara Janssen will defend her PhD thesis at 10:30.
- September 13, 2015: Symposium on Diabetes imaging 2015, Stockholm.
- September 10, 2015: Steven Schalekamp will defend his PhD thesis at 14:30.
- June 23, 2015: Anton Meijer has obtained his PhD with a thesis entitled Clinical Application of Brain MRI - From basic to advanced imaging in Parkinsonism.
- May 27, 2015: Wietske Woliner-van der Weg has obtained her PhD for her thesis Clinical application of quantative SPECT in patient specific dosimetry and beta cell quantification.
- May 22, 2015: Stijn Muselaers has obtained his PhD for his thesis Targeting renal cell carcinoma with radiolabeled antibodies.
- April 25, 2015: Dennis Vriens has obtained his PhD for his thesis Quantitative characterisation of solid tumours by 18F-FDG PET. What's in a number? (cum laude).
- April 24, 2015: Albert Gubern-Mérida has obtained his PhD, entitled Automated Analysis of Magnetic Resonance Imaging of the Breast.
- April 01, 2015: Prof. Johan M Thijssen was honored with a royal decoration. He received the Officer's Cross in the Order of Orange-Nassau for his work on Medical Ultrasound Imaging and for his extensive social activities.
- March 12, 2015: Bob Hamans has obtained his PhD degree for his thesis Magnetic Resonance for non-invasive evaluation of preclinical models of human brain tumors.
For older news, see the News Archive.